REAL-TIME SCHEDULING ON ASYMMETRIC MULTIPROCESSOR PLATFORMS

Real-time scheduling analysis is crucial for time-critical systems, in which provable timing guarantees are more important than observed raw performance. Techniques for real-time scheduling analysis initially targeted uniprocessor platforms but have since evolved to encompass multiprocessor platforms. However, work directed at multiprocessors has largely focused on symmetric platforms, in which every processor is identical. Today, it is common for a multiprocessor to include heterogeneous processing elements, as this offers advantages with respect to size, weight, and power (SWaP) limitations. As a result, realizing modern real-time systems on asymmetric multiprocessor platforms is an inevitable trend. Unfortunately, principles and mechanisms regarding real-time scheduling on such platforms are relatively lacking. The goal of this dissertation is to enrich such principles and mechanisms, by bridging existing analysis for symmetric multiprocessor platforms to asymmetric ones and by developing new techniques that are unique for asymmetric multiprocessor platforms. The specific contributions are threefold. First, for a platform consisting of processors that differ with respect to processing speeds only, this dissertation shows that the preemptive global earliest-deadline-first (G-EDF) scheduler is optimal for scheduling soft real-time (SRT) task systems. Furthermore, it shows that semi-partitioned scheduling, which is a hybrid of conventional global and partitioned scheduling approaches, can be applied to optimally schedule both hard real-time (HRT) and SRT task systems. Second, on platforms that consist of processors with different functionalities, tasks that belong to different functionalities may process the same source data consecutively and therefore have producer/consumer relationships among them, which are represented by directed acyclic graphs (DAGs). End-to-end response-time bounds for such DAGs are derived in this dissertation under a G-EDF-based scheduling approach, and it is shown that such bounds can be improved by a linear-programming-based deadline-setting technique. Third, processor virtualization can lead a symmetric physical platform to be asymmetric. In fact, for a designated virtual-platform capacity, there exist an infinite number of allocation schemes for virtual processors and a choice must be made. In this dissertation, a particular asymmetric virtual-processor allocation scheme, called minimum-parallelism (MP) form, is shown to dominate all other schemes including symmetric ones.Doctor of Philosoph

Knowledge-based clinical pathway for medical quality improvement

Clinical pathways have been adopted for various diseases in clinical departments for quality improvement as a result of standardization of medical activities in treatment process. Using knowledge-based decision support on the basis of clinical pathways is a promising strategy to improve medical quality effectively. However, the clinical pathway knowledge has not been fully integrated into treatment process and thus cannot provide comprehensive support to the actual work practice. Therefore this paper proposes a knowledgebased clinical pathway management method which contributes to make use of clinical knowledge to support and optimize medical practice. We have developed a knowledgebased clinical pathway management system to demonstrate how the clinical pathway knowledge comprehensively supports the treatment process. The experiences from the use of this system show that the treatment quality can be effectively improved by the extracted and classified clinical pathway knowledge, seamless integration of patient-specific clinical pathway recommendations with medical tasks and the evaluating pathway deviations for optimization

CRISPR accelerates the cancer drug discovery

Emerging cohorts and basic studies have associated certain genetic modifications in cancer patients, such as gene mutation, amplification, or deletion, with the overall survival prognosis, underscoring patients??? genetic background may directly regulate drug sensitivity/resistance during chemotherapies. Understanding the molecular mechanism underpinning drug sensitivity/resistance and further uncovering the effective drugs have been the major ambition in the cancer drug discovery. The emergence and popularity of CRISPR/Cas9 technology have reformed the entire life science research, providing a precise and simplified genome editing tool with unlimited editing possibilities. Furthermore, it presents a powerful tool in cancer drug discovery, which hopefully facilitates us with a rapid and reliable manner in developing novel therapies and understanding the molecular mechanisms of drug sensitivity/resistance. Herein, we summarized the application of CRISPR/Cas9 in drug screening, with the focus on CRISPR/Cas9 mediated gene knockout, gene knock-in, as well as transcriptional modification. Additionally, this review provides the concerns, cautions, and ethnic considerations that need to be taken when applying CRISPR in the drug discovery.Peer reviewe

Studies of the Synchronous Sensing Method in the Microfluidic Cell Impedance Detection

Microfluidic impedance sensors play a significant role in point-of-care applications, clinical tests and laboratory studies. Instead of the traditional signal process method with the envelope detector, filter banks and multistage amplifier, we have reported a new implement using synchronous sampling and orthogonal detecting. By studying the intensity and phase modulation in the cell impedance sensing progress, we have calculated the SNR of the new method compare with the raw data. Base on the physical model and the calculation, we have demonstrated a simulation result which shows a capability to detect the signal of 1um cell in a noisy environment

An exquisitely preserved in-ovo theropod dinosaur embryo sheds light on avian-like prehatching postures

Despite the discovery of many dinosaur eggs and nests over the past 100 years, articulated in-ovo embryos are remarkably rare. Here we report an exceptionally preserved, articulated oviraptorid embryo inside an elongatoolithid egg, from the Late Cretaceous Hekou Formation of southern China. The head lies ventral to the body, with the feet on either side, and the back curled along the blunt pole of the egg, in a posture previously unrecognized in a non-avian dinosaur, but reminiscent of a late-stage modern bird embryo. Comparison to other late-stage oviraptorid embryos suggests that prehatch oviraptorids developed avian-like postures late in incubation, which in modern birds are related to coordinated embryonic movements associated with tucking — a behavior controlled by the central nervous system, critical for hatching success. We propose that such pre-hatching behavior, previously considered unique to birds, may have originated among non-avian theropods, which can be further investigated with additional discoveries of embryo fossils

Medical service unity: an effective approach for medical care in rural areas in China

Medical care in rural China has long suffered because of a concentration of medical resources in major hospitals in cities. The patients in rural areas thus do not have affordable access to quality medical services. To tackle such issues, a tiered medical scheme (TMS) was promoted by the Chinese State Council in 2015. It divides hospitals into three tiers and encourages collaborations among different tiers within a region in order to provide better accessibility to medical care for patients in rural areas. The implementation of the TMS policy has not been successful, because the previous funding model, which allocated funding to each hospital according to the number of patients treated, did not facilitate close collaborations between different hospitals. In this report, the medical service unity (MSU) approach, which has been piloted in Funan county, is reported. The MSU organises the tiered hospitals as a unity in terms of medical capabilities and financial abilities. With the radical reform of financial decentralisation, three flows are thereby enabled: the funding flow binds together the hospitals into a unity, the patient flow shares the load across the providers and eases barriers to access, and the resource flow ensures accessibility and affordability for patients. The MSU approach has been shown by the pilot project in Funan to be effective for the realisation of the TMS policy, benefiting hospitals, doctors and patients. The successful experience of the Funan MSU could be introduced to other regions across China and other countries. In particular, future finance reform policies for the health system would largely benefit the health reforms and especially the decentralisation of medical resources to rural areas

Pure and conformal CVD nickel and nickel monosilicide in high-aspect-ratio structures analyzed by atom probe tomography

Low-resistance and uniform contacts are needed for modern 3-D silicon transistors. The formation of high-quality and conformal nickel silicide at the interface between silicon and metal contacts is a possible solution. Direct-liquid-evaporation chemical vapor deposition is used to deposit nickel films conformally inside narrow silicon trenches. The deposited Ni is then reacted with a silicon substrate to form nickel monosilicide. Atom probe tomography (APT) is used to find and count the atoms in nanoscale regions inside these 3-D structures. APT shows that these NiSi films are stoichiometrically pure, single-phase, and conformal even inside trenches with high aspect ratios. The APT technique measures all impurities, including carbon, nitrogen, and oxygen, to have concentrations less than 0.1 at. %.Chemistry and Chemical Biolog

Towards Advantages of Parameterized Quantum Pulses

The advantages of quantum pulses over quantum gates have attracted increasing attention from researchers. Quantum pulses offer benefits such as flexibility, high fidelity, scalability, and real-time tuning. However, while there are established workflows and processes to evaluate the performance of quantum gates, there has been limited research on profiling parameterized pulses and providing guidance for pulse circuit design. To address this gap, our study proposes a set of design spaces for parameterized pulses, evaluating these pulses based on metrics such as expressivity, entanglement capability, and effective parameter dimension. Using these design spaces, we demonstrate the advantages of parameterized pulses over gate circuits in the aspect of duration and performance at the same time thus enabling high-performance quantum computing. Our proposed design space for parameterized pulse circuits has shown promising results in quantum chemistry benchmarks.Comment: 11 Figures, 4 Table

Elucidating the molecular determinants in the process of gastrin C-terminal pentapeptide amide end activating cholecystokinin 2 receptor by Gaussian accelerated molecular dynamics simulations

Gastrin plays important role in stimulating the initiation and development of many gastrointestinal diseases through interacting with the cholecystokinin 2 receptor (CCK2R). The smallest bioactive unit of gastrin activating CCK2R is the C-terminal tetrapeptide capped with an indispensable amide end. Understanding the mechanism of this smallest bioactive unit interacting with CCK2R on a molecular basis could provide significant insights for designing CCK2R antagonists, which can be used to treat gastrin-related diseases. To this end, we performed extensive Gaussian accelerated molecular dynamics simulations to investigate the interaction between gastrin C-terminal pentapeptide capped with/without amide end and CCK2R. The amide cap influences the binding modes of the pentapeptide with CCK2R by weakening the electrostatic attractions between the C-terminus of the pentapeptide and basic residues near the extracellular domain in CCK2R. The C-terminus with the amide cap penetrates into the transmembrane domain of CCK2R while floating at the extracellular domain without the amide cap. Different binding modes induced different conformational dynamics of CCK2R. Residue pairs in CCK2R had stronger correlated motions when binding with the amidated pentapeptide. Key residues and interactions important for CCK2R binding with the amidated pentagastrin were also identified. Our results provide molecular insights into the determinants of the bioactive unit of gastrin activating CCK2R, which would be of great help for the design of CCK2R antagonists